Skin and HCV : Most of the signs and symptoms of HCV relate to the liver. Less commonly, HCV causes conditions outside of the liver.
Close-up view of lichen planus.
Extrahepatic Manifestations: Skin
One-third to one-half of people with chronic hepatitis C infection have cryoglobulinemia (antibodies in the bloodstream attached to the hepatitis C RNA that happen to solidify when cold). , Hepatitis C is recognized as the most common cause of mixed cryoglobulinemia. Most of the people with cryoglobulinemia from hepatitis C have had their hepatitis for a long time or have cirrhosis. People with higher concentrations of hepatitis C RNA in their blood do not seem to have a higher risk of having cryoglobulinemia. Usually the cryoglobulins are in low concentration and cause no symptoms. About twenty-percent of people with hepatitis C and cryoglobulinemia have symptoms. Symptoms most often associated with cryoglobulinemia include mild fatigue, joint pains, or itching. ,
Occasionally, people with cryoglobulinemia develop vasculitis (inflammation of the blood vessels) which can cause purpura (purple skin lesions), Raynaud's phenomenon (the hands turn white, then blue, and then red from constriction and subsequent dilation of the blood vessels), or numbness in the hands and feet. The presence of cryoglobulinemia does not effect people's response to interferon. In fact, some people with vasculitis have improvement in the vasculitis as their liver tests improve on interferon.
Lichen Planus and Porphyria Cutanea Tarda :
Two skin conditions, lichen planus and porphyria cutanea tarda, have been associated with chronic hepatitis C virus. It is important to know that both of these skin conditions can resolve with successful interferon therapy for the hepatitis C virus. ,
Also See Rituximab Plus Peg-Interferon-alpha/Ribavirin Compared with Peg-Interferon-alpha/Ribavirin in Hepatitis C-Related Mixed Cryoglobulinemia
Related - Skin can show first signs of some internal diseases
Skin Rash In Patients Treating With Telaprevir
2013 - 2012
FDA Drug Safety Podcast: Serious skin reactions after combination treatment with the Hepatitis C drugs
Incivek (telaprevir), peginterferon alfa, and ribavirin
FDA Drug Safety Communication/Data Summary: Serious skin reactions after combination
treatment with the Hepatitis C drugs Incivek (telaprevir), peginterferon alfa, and ribavirin
INCIVEK® (telaprevir)-Updates label after reports of a ‘small number of fatal skin reactions’
Incivek-Help Recognizing Rash Severity:Photos and grading system
Skin Rash During HCV Therapy/Pictures
HCV Triple-therapy Side Effects
Other Updates 2010-2011
Skin findings In Hepatitis C
Rash Hepatitis C /Lichen planus /Photos
HCV Rash; Mixed Cryoglobulinemia/Photos
Hepatitis C Rash: Porphyria cutanea tarda/Photos